Publication: OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control
OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control
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Ruiz-Serrano, A., Monné Rodríguez, J. M., Günter, J., Sherman, S. P. M., Jucht, A. E., Fluechter, P., Volkova, Y. L., Pfundstein, S., Pellegrini, G., Wagner, C. A., Schneider, C., Wenger, R. H., & Scholz, C. C. (2021). OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control. FASEB Journal, 35(12), e22039. https://doi.org/10.1096/fj.202100346R
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OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. However, the physiological function of OTUB1 is unknown. Here, we show that constitutive whole-body Otub1 deletion in mice leads to perinatal lethality by asphyxiation. Analysis of (single-cell) RNA sequencing and proteome data demonstrated that OTUB1 is expressed in all lung cell types with a
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Ruiz-Serrano, A., Monné Rodríguez, J. M., Günter, J., Sherman, S. P. M., Jucht, A. E., Fluechter, P., Volkova, Y. L., Pfundstein, S., Pellegrini, G., Wagner, C. A., Schneider, C., Wenger, R. H., & Scholz, C. C. (2021). OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control. FASEB Journal, 35(12), e22039. https://doi.org/10.1096/fj.202100346R
