Publication: Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy
Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy
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Hartkopf, A. D., Müller, V., Wöckel, A., Lux, M. P., Janni, W., Ettl, J., Belleville, E., Schütz, F., Fasching, P. A., Kolberg, H.-C., Welslau, M., Overkamp, F., Taran, F.-A., Brucker, S. Y., Wallwiener, M., Tesch, H., Fehm, T. N., Schneeweiss, A., & Lüftner, D. (2019). Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy. Geburtshilfe Und Frauenheilkunde, 79(12), 1309–1319. https://doi.org/10.1055/a-1039-4458
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In the near future, important translational questions of clinical relevance will be adressed by studies currently in progress. On the one hand, the role of PD-L1 expression must be further understood, after it was found to be relevant in the use of atezolizumab in first-line therapy of patients with metastatic triple-negative breast cancer (TNBC). No association between efficacy and PD-L1 expression was found in a neoadjuvant study that included pembrolizumab in TNBC. The pathological complete response rate (pCR) was higher in both pa
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Hartkopf, A. D., Müller, V., Wöckel, A., Lux, M. P., Janni, W., Ettl, J., Belleville, E., Schütz, F., Fasching, P. A., Kolberg, H.-C., Welslau, M., Overkamp, F., Taran, F.-A., Brucker, S. Y., Wallwiener, M., Tesch, H., Fehm, T. N., Schneeweiss, A., & Lüftner, D. (2019). Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy. Geburtshilfe Und Frauenheilkunde, 79(12), 1309–1319. https://doi.org/10.1055/a-1039-4458