Publication: DNA Methylation in Healthy Older Adults With a History of Childhood Adversity-Findings From the Women 40+ Healthy Aging Study
DNA Methylation in Healthy Older Adults With a History of Childhood Adversity-Findings From the Women 40+ Healthy Aging Study
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Fiacco, S., Gardini, E. S., Mernone, L., Schick, L., & Ehlert, U. (2019). DNA Methylation in Healthy Older Adults With a History of Childhood Adversity-Findings From the Women 40+ Healthy Aging Study. Frontiers in Psychiatry, 10, 777. https://doi.org/10.3389/fpsyt.2019.00777
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Background: Adversity in early development seems to increase the risk of stress-related somatic disorders later in life. Physiologically, functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes is often discussed as long-term mediators of risk. In particular, DNA methylation in the glucocorticoid receptor gene promoter (NR3C1) has been associated with type and strength of early life adversity and subsequent effects on HPA axis signaling in humans. Animal studies, moreover, suggest changes in DNA methy
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- Fiacco, Serena
- Gardini, Elena Silvia
- Mernone, Laura
- Schick, Lea
- Ehlert, Ulrike
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Fiacco, S., Gardini, E. S., Mernone, L., Schick, L., & Ehlert, U. (2019). DNA Methylation in Healthy Older Adults With a History of Childhood Adversity-Findings From the Women 40+ Healthy Aging Study. Frontiers in Psychiatry, 10, 777. https://doi.org/10.3389/fpsyt.2019.00777
