Publication: Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
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Kreutmair, S., Unger, S., Núñez, N. G., Ingelfinger, F., Alberti, C., De Feo, D., Krishnarajah, S., Kauffmann, M., Friebel, E., Babaei, S., Gaborit, B., Lutz, M., Jurado, N. P., Malek, N. P., Goepel, S., Rosenberger, P., Häberle, H. A., Ayoub, I., Al-Hajj, S., … Becher, B. (2021). Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia. Immunity, 54(7), 1578-1593.e5. https://doi.org/10.1016/j.immuni.2021.05.002
Abstract
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Immune profiling of COVID-19 patients has identified numerous alterations in both innate and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or driven by a general inflammatory response shared across severely ill pneumonia patients remains unknown. Here, we compared the immune profile of severe COVID-19 with non-SARS-CoV-2 pneumonia ICU patients using longitudinal, high-dimensional single-cell spectral cytometry and algorithm-guided analysis. COVID-19 and non-SARS-CoV-2 pneumonia both showed increased emer
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Creators (Authors)
- Kreutmair, Stefanie
- Unger, Susanne
- Núñez, Nicolás Gonzalo
- Ingelfinger, Florian
- Alberti, Chiara
- De Feo, Donatella
- Krishnarajah, Sinduya
- Kauffmann, Manuel
- Friebel, Ekaterina
- Babaei, Sepideh
- Gaborit, Benjamin
- Lutz, Mirjam
- Jurado, Nicole Puertas
- Malek, Nisar P
- Goepel, Siri
- Rosenberger, Peter
- Häberle, Helene A
- Ayoub, Ikram
- Al-Hajj, Sally
- Nilsson, Jakob
- Claassen, Manfred
- Liblau, Roland
- Martin-Blondel, Guillaume
- Bitzer, Michael
- Roquilly, Antoine
- Becher, Burkhard
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Citations
Kreutmair, S., Unger, S., Núñez, N. G., Ingelfinger, F., Alberti, C., De Feo, D., Krishnarajah, S., Kauffmann, M., Friebel, E., Babaei, S., Gaborit, B., Lutz, M., Jurado, N. P., Malek, N. P., Goepel, S., Rosenberger, P., Häberle, H. A., Ayoub, I., Al-Hajj, S., … Becher, B. (2021). Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia. Immunity, 54(7), 1578-1593.e5. https://doi.org/10.1016/j.immuni.2021.05.002
