Publication: CNS immune surveillance and neuroinflammation: endocannabinoids keep control
CNS immune surveillance and neuroinflammation: endocannabinoids keep control
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Wolf, S. A., Tauber, S., & Ullrich, O. (2008). CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Current Pharmaceutical Design, 14(23), 2266–2278. https://doi.org/10.2174/138161208785740090
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To avoid inflammatory escalation, the central nervous system (CNS) harbors an impressive arsenal of cellular and molecular mechanisms enabling strict control of immune reactions. We here summarize studies suggesting that the old paradigm of the "CNS immune privilege" is overly simplistic. The immune system is allowed to keep the CNS under surveillance, but in a strictly controlled, limited and well-regulated manner. The first line of defense lies outside the brain parenchyma to spare neuronal tissue from the detrimental effects of an
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- Wolf, S A
- Tauber, S
- Ullrich, O
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Wolf, S. A., Tauber, S., & Ullrich, O. (2008). CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Current Pharmaceutical Design, 14(23), 2266–2278. https://doi.org/10.2174/138161208785740090