Publication: Patupilone (Epothilone B) for recurrent glioblastoma: Clinical outcome and translational analysis of a single-institution phase I/II trial
Patupilone (Epothilone B) for recurrent glioblastoma: Clinical outcome and translational analysis of a single-institution phase I/II trial
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Oehler, C., Frei, K., Rushin, E. J., McSheehy, P. M. J., Weber, D., Allegrini, P. R., Weniger, D., Lütolf, U. M., Knuth, A., Yonekawa, Y., Barath, K., Broggini-Tenzer, A., Pruschy, M., & Hofer, S. (2012). Patupilone (Epothilone B) for recurrent glioblastoma: Clinical outcome and translational analysis of a single-institution phase I/II trial. Oncology, 83(1), 1–9. https://doi.org/10.1159/000339152
Abstract
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Background: Patients with glioblastoma (GBM) inevitably develop recurrent or progressive disease after initial multimodal treatment and have a median survival of 6-9 months from time of progression. To date, there is no accepted standard treatment for GBM relapse or progression. Patupilone (EPO906) is a novel natural microtubule-stabilizing cytotoxic agent that crosses the blood-brain barrier and has been found to have preclinical activity in glioma models. Methods: This is a single-institution, early-phase I/II trial of GBM patients
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- McSheehy, P M J
- Weber, D
- Allegrini, P R
- Weniger, D
- Knuth, A
- Barath, K
- Hofer, S
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Oehler, C., Frei, K., Rushin, E. J., McSheehy, P. M. J., Weber, D., Allegrini, P. R., Weniger, D., Lütolf, U. M., Knuth, A., Yonekawa, Y., Barath, K., Broggini-Tenzer, A., Pruschy, M., & Hofer, S. (2012). Patupilone (Epothilone B) for recurrent glioblastoma: Clinical outcome and translational analysis of a single-institution phase I/II trial. Oncology, 83(1), 1–9. https://doi.org/10.1159/000339152
