Publication: Non-Canonical Control of Neuronal Energy Status by the Na+ Pump
Non-Canonical Control of Neuronal Energy Status by the Na+ Pump
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Baeza-Lehnert, F., Saab, A. S., Gutiérrez, R., Larenas, V., Díaz, E., Horn, M., Vargas, M., Hösli, L., Stobart, J., Hirrlinger, J., Weber, B., & Barros, L. F. (2019). Non-Canonical Control of Neuronal Energy Status by the Na+ Pump. Cell Metabolism, 29(3), 668-680.e4. https://doi.org/10.1016/j.cmet.2018.11.005
Abstract
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Abstract
Neurons have limited intracellular energy stores but experience acute and unpredictable increases in energy demand. To better understand how these cells repeatedly transit from a resting to active state without undergoing metabolic stress, we monitored their early metabolic response to neurotransmission using ion-sensitive probes and FRET sensors in vitro and in vivo. A short theta burst triggered immediate Na+ entry, followed by a delayed stimulation of the Na+/K+ ATPase pump. Unexpectedly, cytosolic ATP and ADP levels were unperturb
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- Baeza-Lehnert, Felipe
- Saab, Aiman S
- Gutiérrez, Robin
- Larenas, Valeria
- Díaz, Esteban
- Horn, Melanie
- Vargas, Miriam
- Hösli, Ladina
- Stobart, Jillian
- Hirrlinger, Johannes
- Weber, Bruno
- Barros, L Felipe
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Baeza-Lehnert, F., Saab, A. S., Gutiérrez, R., Larenas, V., Díaz, E., Horn, M., Vargas, M., Hösli, L., Stobart, J., Hirrlinger, J., Weber, B., & Barros, L. F. (2019). Non-Canonical Control of Neuronal Energy Status by the Na+ Pump. Cell Metabolism, 29(3), 668-680.e4. https://doi.org/10.1016/j.cmet.2018.11.005