Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice

Antsiferova, Olga; Müller, Anne; Rämer, Patrick C; Chijioke, Obinna; Chatterjee, Bithi; Raykova, Ana; Planas, Raquel; Sospedra, Mireia; Shumilov, Anatoliy; Tsai, Ming-Han; Delecluse, Henri-Jacques; Münz, Christian

doi:10.1371/journal.ppat.1004333

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Antsiferova, O., Müller, A., Rämer, P. C., Chijioke, O., Chatterjee, B., Raykova, A., Planas, R., Sospedra, M., Shumilov, A., Tsai, M.-H., Delecluse, H.-J., & Münz, C. (2014). Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice. PLoS Pathogens, 10(8), e1004333. https://doi.org/10.1371/journal.ppat.1004333

Abstract

Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice).