Publication: Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone
Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone
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Ghayor, C., Correro, R. M., Lange, K., Karfeld-Sulzer, L. S., Grätz, K. W., & Weber, F. E. (2011). Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone. Journal of Biological Chemistry, 286(27), 24458–24466. https://doi.org/10.1074/jbc.M111.223297
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Regulation of RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclast differentiation is of current interest in the development of antiresorptive agents. Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of N-methylpyrrolidone (NMP) on the regulation of RANKL-induced osteoclastogenesis. NMP inhibited RANKL-induced tartrate-resistant acid phosphatase activity and the formation of tartrate-resistant acid phosphatase-positive multinucleated cells
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- Ghayor, C
- Correro, R M
- Lange, K
- Karfeld-Sulzer, L S
- Grätz, K W
- Weber, Franz E
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Ghayor, C., Correro, R. M., Lange, K., Karfeld-Sulzer, L. S., Grätz, K. W., & Weber, F. E. (2011). Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone. Journal of Biological Chemistry, 286(27), 24458–24466. https://doi.org/10.1074/jbc.M111.223297
