Publication: Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen
Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen
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Crespan, E., Pasi, E., Imoto, S., Hübscher, U., Greenberg, M. M., & Maga, G. (2013). Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen. ACS Chemical Biology, 8(2), 336–344. https://doi.org/10.1021/cb300542k
Abstract
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The C1'-oxidized lesion 2-deoxyribonolactone (L) is induced by free radical attack of DNA. This lesion is mutagenic, inhibits base excision repair, and can lead to strand scission. In double-stranded DNA L is repaired by long-patch base excision repair, but it induces replication fork arrest in a single-strand template. Translesion synthesis requires a specialized DNA polymerase (Pol). In E. coli, Pol V is responsible for bypassing L, whereas in yeast Pol ζ has been shown to be required for efficient bypass. Very little is known about
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- Crespan, Emmanuele
- Pasi, Emanuela
- Imoto, Shuhei
- Hübscher, Ulrich
- Greenberg, Marc M
- Maga, Giovanni
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Crespan, E., Pasi, E., Imoto, S., Hübscher, U., Greenberg, M. M., & Maga, G. (2013). Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen. ACS Chemical Biology, 8(2), 336–344. https://doi.org/10.1021/cb300542k