Platinum(II) and Copper(II) complexes of asymmetric halogen-substituted [NNʹO] ligands: Synthesis, characterization, structural investigations and antiproliferative activity

Amiri Rudbari, Hadi; Saadati, Arezoo; Aryaeifar, Mahnaz; Blacque, Olivier; Cuevas-Vicario, Jose V; Cabral, Rui; Raposo, Luis R; Fernandes, Alexandra R

doi:10.1016/j.bioorg.2021.105556

Citations

Citation copied

Amiri Rudbari, H., Saadati, A., Aryaeifar, M., Blacque, O., Cuevas-Vicario, J. V., Cabral, R., Raposo, L. R., & Fernandes, A. R. (2022). Platinum(II) and Copper(II) complexes of asymmetric halogen-substituted [NNʹO] ligands: Synthesis, characterization, structural investigations and antiproliferative activity. Bioorganic Chemistry, 119, 105556. https://doi.org/10.1016/j.bioorg.2021.105556

Abstract

In order to better understand the effect of structure, halogen substitution, metal ions and ligand flexibility on antiproliferative activity, eight Cu(II) complexes and eight Pt(II) complexes were obtained of 2,4-X1,X2-6-((pyridine-2-ylmethylamino)methyl)phenol and 2,4-X1,X2-6-((pyridine-2-ylmethylamino)ethyl)phenol (where X is Cl, Br, or I) ligands. The compounds were characterized with various techniques, such as FT-IR, NMR, elemental analysis and single-crystal X-ray diffraction (SCXRD). The X-ray structures showed that ligand acts