Publication: Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain
Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain
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Casano, A. M., Albert, M., & Peri, F. (2016). Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain. Cell Reports, 16(4), 897–906. https://doi.org/10.1016/j.celrep.2016.06.033
Abstract
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Abstract
In the brain, neurons that fail to assemble into functional circuits are eliminated. Their clearance depends on microglia, immune cells that colonize the CNS during embryogenesis. Despite the importance of these cells in development and disease, the mechanisms that target and position microglia within the brain are unclear. Here we show that, in zebrafish, attraction of microglia into the brain exploits differences in developmental neuronal apoptosis and that these provide a mechanism for microglial distribution. Reducing neuronal cel
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- Casano, Alessandra Maria
- Albert, Marvin
- Peri, Francesca
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Casano, A. M., Albert, M., & Peri, F. (2016). Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain. Cell Reports, 16(4), 897–906. https://doi.org/10.1016/j.celrep.2016.06.033
