Linking genomo- and pathotype: Exploiting the Zebrafish embryo model to investigate the divergent virulence potential among cronobacter spp

Eshwar, Athmanya K; Tall, Ben D; Gangiredla, Jayanthi; Gopinath, Gopal R; Patel, Isha R; Neuhauss, Stephan C F; Stephan, Roger; Lehner, Angelika

doi:10.1371/journal.pone.0158428

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Eshwar, A. K., Tall, B. D., Gangiredla, J., Gopinath, G. R., Patel, I. R., Neuhauss, S. C. F., Stephan, R., & Lehner, A. (2016). Linking genomo- and pathotype: Exploiting the Zebrafish embryo model to investigate the divergent virulence potential among cronobacter spp. PLoS ONE, 11(6), e0158428. https://doi.org/10.1371/journal.pone.0158428

Abstract

Bacteria belonging to the genus Cronobacter have been recognized as causative agents of life-threatening systemic infections primarily in premature, low-birth weight and immune-compromised neonates. Apparently not all Cronobacter species are linked to infantile infections and it has been proposed that virulence varies among strains. Whole genome comparisons and in silico analysis have proven to be powerful tools in elucidating potential virulence determinants, the presence/absence of which may explain the differential virulence behavi