Publication: Cell-to-cell and genome-to-genome variability of adenovirus transcription tuned by the cell cycle
Cell-to-cell and genome-to-genome variability of adenovirus transcription tuned by the cell cycle
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Suomalainen, M., Prasad, V., Kannan, A., & Greber, U. F. (2020). Cell-to-cell and genome-to-genome variability of adenovirus transcription tuned by the cell cycle. Journal of Cell Science, jcs.252544. https://doi.org/10.1242/jcs.252544
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In clonal cultures, not all cells are equally susceptible to virus infection and the underlying mechanisms are poorly understood. Here, we developed image-based single cell measurements to scrutinize the heterogeneity of adenovirus (AdV) infection. AdV delivers, transcribes and replicates a linear double-stranded DNA genome in the nucleus. We measured the abundance of viral transcripts by single-molecule RNA fluorescence in situ hybridization (FISH), and the incoming ethynyl-deoxy-cytidine (EdC)-tagged viral genomes by copper(I)-catal
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- Suomalainen, Maarit
- Prasad, Vibhu
- Kannan, Abhilash
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Suomalainen, M., Prasad, V., Kannan, A., & Greber, U. F. (2020). Cell-to-cell and genome-to-genome variability of adenovirus transcription tuned by the cell cycle. Journal of Cell Science, jcs.252544. https://doi.org/10.1242/jcs.252544
