Publication: Tracking viral genomes in host cells at single-molecule resolution
Tracking viral genomes in host cells at single-molecule resolution
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Wang, I.-H., Suomalainen, M., Andriasyan, V., Kilcher, S., Mercer, J., Neef, A., Luedtke, N. W., & Greber, U. F. (2013). Tracking viral genomes in host cells at single-molecule resolution. Cell Host & Microbe, 14(4), 468–480. https://doi.org/10.1016/j.chom.2013.09.004
Abstract
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Abstract
Viral DNA trafficking in cells has large impacts on physiology and disease development. Current methods lack the resolution and accuracy to visualize and quantify viral DNA trafficking at single-molecule resolution. We developed a noninvasive protocol for accurate quantification of viral DNA-genome (vDNA) trafficking in single cells. Ethynyl-modified nucleosides were used to metabolically label newly synthesized adenovirus, herpes virus, and vaccinia virus vDNA, without affecting infectivity. Superresolution microscopy and copper(I)-c
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- Wang, I-Hsuan
- Suomalainen, Maarit
- Andriasyan, Vardan
- Kilcher, Samuel
- Mercer, Jason
- Neef, Anne
- Luedtke, Nathan W
- Greber, Urs F
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Wang, I.-H., Suomalainen, M., Andriasyan, V., Kilcher, S., Mercer, J., Neef, A., Luedtke, N. W., & Greber, U. F. (2013). Tracking viral genomes in host cells at single-molecule resolution. Cell Host & Microbe, 14(4), 468–480. https://doi.org/10.1016/j.chom.2013.09.004
