Publication: Immunity to Intracellular Salmonella Depends on Surface-associated Antigens
Immunity to Intracellular Salmonella Depends on Surface-associated Antigens
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Barat, S., Willer, Y., Rizos, K., Claudi, B., Mazé, A., Schemmer, A. K., Kirchhoff, D., Schmidt, A., Burton, N., & Bumann, D. (2012). Immunity to Intracellular Salmonella Depends on Surface-associated Antigens. PLoS Pathogens, 8(10), e1002966. https://doi.org/10.1371/journal.ppat.1002966
Abstract
Abstract
Abstract
Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum. Novel vaccines with broad serovar coverage are needed, but suitable protective antigens remain largely unknown. Here, we tested 37 broadly conserved Salmonella antigens in a mouse typhoid fever model, and identified antigen candidates that conferred partial protection against lethal disease. Antigen properties such as high in vivo abundance or immunodominance in convalescen
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- Barat, Somedutta
- Willer, Yvonne
- Rizos, Konstantin
- Claudi, Beatrice
- Mazé, Alain
- Schemmer, Anne K
- Kirchhoff, Dennis
- Schmidt, Alexander
- Burton, Neil
- Bumann, Dirk
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Barat, S., Willer, Y., Rizos, K., Claudi, B., Mazé, A., Schemmer, A. K., Kirchhoff, D., Schmidt, A., Burton, N., & Bumann, D. (2012). Immunity to Intracellular Salmonella Depends on Surface-associated Antigens. PLoS Pathogens, 8(10), e1002966. https://doi.org/10.1371/journal.ppat.1002966
