Krüppel-Like Factor 10 participates in cervical cancer immunoediting through transcriptional regulation of Pregnancy-Specific Beta-1 Glycoproteins

Marrero-Rodríguez, Daniel; Taniguchi-Ponciano, Keiko; Subramaniam, Malayannan; Hawse, John R; Pitel, Kevin S; Arreola-De la Cruz, Hugo; Huerta-Padilla, Victor; Ponce-Navarrete, Gustavo; Figueroa-Corona, Ma Del Pilar; Gomez-Virgilio, Laura; Martinez-Cuevas, Teresa I; Mendoza-Rodriguez, Monica; Rodriguez-Esquivel, Miriam; Romero-Morelos, Pablo; Ramirez-Salcedo, Jorge; Baudis, Michael; Meraz-Rios, Marco; Jimenez-Vega, Florinda; Salcedo, Mauricio

doi:10.1038/s41598-018-27711-8

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Marrero-Rodríguez, D., Taniguchi-Ponciano, K., Subramaniam, M., Hawse, J. R., Pitel, K. S., Arreola-De la Cruz, H., Huerta-Padilla, V., Ponce-Navarrete, G., Figueroa-Corona, M. D. P., Gomez-Virgilio, L., Martinez-Cuevas, T. I., Mendoza-Rodriguez, M., Rodriguez-Esquivel, M., Romero-Morelos, P., Ramirez-Salcedo, J., Baudis, M., Meraz-Rios, M., Jimenez-Vega, F., & Salcedo, M. (2018). Krüppel-Like Factor 10 participates in cervical cancer immunoediting through transcriptional regulation of Pregnancy-Specific Beta-1 Glycoproteins. Scientific Reports, 8(1), 9445. https://doi.org/10.1038/s41598-018-27711-8

Abstract

Cervical cancer (CC) is associated with alterations in immune system balance, which is primarily due to a shift from Th1 to Th2 and the unbalance of Th17/Treg cells. Using in silico DNA copy number analysis, we have demonstrated that ~20% of CC samples exhibit gain of 8q22.3 and 19q13.31; the regions of the genome that encodes the KLF10 and PSG genes, respectively. Gene expression studies demonstrated that there were no alterations in KLF10 mRNA expression, whilst the PSG2 and -5 genes were up-regulated by 1.76 and 3.97-fold respectiv