Publication: USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability
USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability
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Faresse, N., Debonneville, A., & Staub, O. (2013). USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability. Cellular Physiology and Biochemistry, 31(2–3), 462–472. https://doi.org/10.1159/000343382
Abstract
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Abstract
BACKGROUND/AIMS: Ligand activation of the mineralocorticoid receptor (MR) induces several post-translational modifications (PTMs). Among the different PTMs, MR is known to be dynamically ubiquitylated with impact on its stability and transcriptional activity. Previously, we have shown that MR is monoubiquitylated at the basal state and that aldosterone stimulation induces monoubiquitylation removal prompting polyubiquitin-dependent destabilization of the receptor and proteasomal degradation. This study investigated the role of the ald
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- Faresse, Nourdine
- Debonneville, Anne
- Staub, Olivier
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Citations
Faresse, N., Debonneville, A., & Staub, O. (2013). USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability. Cellular Physiology and Biochemistry, 31(2–3), 462–472. https://doi.org/10.1159/000343382
