Publication: Immunohistochemical expression of MDR1-Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype
Immunohistochemical expression of MDR1-Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype
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Finotello, R., Monné Rodríguez, J. M., Vilafranca, M., Altimira, J., Ramirez, G. A., Haines, A., & Ressel, L. (2017). Immunohistochemical expression of MDR1-Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype. Veterinary and Comparative Oncology, 15, 1393–1402. https://doi.org/10.1111/vco.12281
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Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P-glycoprotein 1 (Pgp) expression is a well-recognized feature of multi-drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012-
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- Finotello, R
- Monné Rodríguez, Josep M
- Vilafranca, M
- Altimira, J
- Ramirez, G A
- Haines, A
- Ressel, L
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Finotello, R., Monné Rodríguez, J. M., Vilafranca, M., Altimira, J., Ramirez, G. A., Haines, A., & Ressel, L. (2017). Immunohistochemical expression of MDR1-Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype. Veterinary and Comparative Oncology, 15, 1393–1402. https://doi.org/10.1111/vco.12281
