Publication: Development of a Cellular Assay as a Personalized Model for Testing Chronic Wound Therapeutics
Development of a Cellular Assay as a Personalized Model for Testing Chronic Wound Therapeutics
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Doerfler, P., Schoefmann, N., Cabral, G., Bauer, W., Berli, M. C., Binder, B., Borst, C., Botter, S., French, L. E., Goerge, T., Hafner, J., Hartmann, D., Høgh, A., Hoetzenecker, W., Holzer-Geissler, J. C. J., Kamolz, L. P., Kofler, K., Luger, T., Nischwitz, S. P., … et al. (2025). Development of a Cellular Assay as a Personalized Model for Testing Chronic Wound Therapeutics. Journal of Investigative Dermatology, 145(3), 631-644.e22. https://doi.org/10.1016/j.jid.2024.05.029
Abstract
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Abstract
Exudates of nonhealing wounds contain drivers of pathogenicity. We utilized >800 exudates from nonhealing and healing wounds of diverse etiologies, collected by 3 different methods, to develop a wound-specific, cell-based functional biomarker assay. Human dermal fibroblast proliferation served as readout to (i) differentiate between healing and nonhealing wounds, (ii) follow the healing process of individual patients, and (iii) assess the effects of therapeutics for chronic wounds ex vivo. We observed a strong correlation between woun
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Creators (Authors)
- Doerfler, Petra
- Schoefmann, Nicole
- Cabral, Gabriela
- Bauer, Wolfgang
- Berli, Martin C
- Binder, Barbara
- Borst, Carina
- Botter, Sander
- French, Lars E
- Goerge, Tobias
- Hafner, Juerg
- Hartmann, Daniela
- Høgh, Annette
- Hoetzenecker, Wolfram
- Holzer-Geissler, Judith C J
- Kamolz, Lars P
- Kofler, Katrin
- Luger, Thomas
- Nischwitz, Sebastian P
- Popovits, Michael
- Rappersberger, Klemens
- Restivo, Gaetana
- Schlager, Justin G
- Schmuth, Matthias
- Stingl, Georg
- Stockinger, Theresa
- Stroelin, Anke
- Stuetz, Anton
- Umlauft, Julian
- Weninger, Wolfgang P
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Doerfler, P., Schoefmann, N., Cabral, G., Bauer, W., Berli, M. C., Binder, B., Borst, C., Botter, S., French, L. E., Goerge, T., Hafner, J., Hartmann, D., Høgh, A., Hoetzenecker, W., Holzer-Geissler, J. C. J., Kamolz, L. P., Kofler, K., Luger, T., Nischwitz, S. P., … et al. (2025). Development of a Cellular Assay as a Personalized Model for Testing Chronic Wound Therapeutics. Journal of Investigative Dermatology, 145(3), 631-644.e22. https://doi.org/10.1016/j.jid.2024.05.029
