Publication: A lymphotoxin-driven pathway to hepatocellular carcinoma
A lymphotoxin-driven pathway to hepatocellular carcinoma
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Haybaeck, J., Zeller, N., Wolf, M. J., Weber, A., Wagner, U., Kurrer, M. O., Bremer, J., Iezzi, G., Graf, R., Clavien, P. A., Thimme, R., Blum, H., Nedospasov, S. A., Zatloukal, K., Ramzan, M., Ciesek, S., Pietschmann, T., Marche, P. N., Karin, M., … Heikenwalder, M. (2009). A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell, 16, 295–308. https://doi.org/10.1016/j.ccr.2009.08.021
Abstract
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Abstract
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) alpha and beta and their receptor (LTbetaR) are upregulated in HBV- or HCV-induced hepatitis and HCC. Liver-specific LTalphabeta expression in mice induces liver inflammation and HCC, causally linking hepatic LT overexpression to hepatitis and HCC. Development of HCC, composed in part of A6(+) oval cells, depends on lymphocytes and IKappa B kinase beta expressed by
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Creators (Authors)
- Haybaeck, J
- Zeller, N
- Wolf, M J
- Weber, A
- Wagner, U
- Kurrer, M O
- Bremer, J
- Iezzi, G
- Graf, R
- Clavien, P A
- Thimme, R
- Blum, H
- Nedospasov, S A
- Zatloukal, K
- Ramzan, M
- Ciesek, S
- Pietschmann, T
- Marche, P N
- Karin, M
- Kopf, M
- Browning, J L
- Heikenwalder, M
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Publications of Clinic for Visceral and Transplantation Surgery
Publications of Division of Surgical Research
Publications of Institute of Neuropathology
Publications of Institute of Pathology and Molecular Pathology
Publications of Systems Biology / Functional Genomics
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Haybaeck, J., Zeller, N., Wolf, M. J., Weber, A., Wagner, U., Kurrer, M. O., Bremer, J., Iezzi, G., Graf, R., Clavien, P. A., Thimme, R., Blum, H., Nedospasov, S. A., Zatloukal, K., Ramzan, M., Ciesek, S., Pietschmann, T., Marche, P. N., Karin, M., … Heikenwalder, M. (2009). A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell, 16, 295–308. https://doi.org/10.1016/j.ccr.2009.08.021
