Publication: Cellular uptake of metallated cobalamins
Cellular uptake of metallated cobalamins
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Tran, M. T. Q., Stürup, S., Lambert, I. H., Gammelgaard, B., Furger, E., & Alberto, R. (2016). Cellular uptake of metallated cobalamins. Metallomics, 8(3), 298–304. https://doi.org/10.1039/C5MT00272A
Abstract
Abstract
Abstract
Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass spectrometry (ICP-MS). Vitamin B12 (cyano-cob(III)alamin) and aquo-cob(III)alamin [Cbl-OH2]+, which differ in the β-axial ligands (CN− and H2O, respectively), were included as control samples. The results indicated that B12 derivatives delivered cisplatin to both cellular cytosol and nuclei with an efficiency of one third compared to the uptake of free cisplatin cis-[PtIICl2(NH
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- Tran, Mai Thanh Quynh
- Stürup, Stefan
- Lambert, Ian Henry
- Gammelgaard, Bente
- Furger, Evelyne
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Tran, M. T. Q., Stürup, S., Lambert, I. H., Gammelgaard, B., Furger, E., & Alberto, R. (2016). Cellular uptake of metallated cobalamins. Metallomics, 8(3), 298–304. https://doi.org/10.1039/C5MT00272A