Publication: Prefrontal Thinning Affects Functional Connectivity and Regional Homogeneity of the Anterior Cingulate Cortex in Depression
Prefrontal Thinning Affects Functional Connectivity and Regional Homogeneity of the Anterior Cingulate Cortex in Depression
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Späti, J., Hänggi, J., Doerig, N., Ernst, J., Sambataro, F., Brakowski, J., Jäncke, L., Grosse Holtforth, M., Seifritz, E., & Spinelli, S. (2015). Prefrontal Thinning Affects Functional Connectivity and Regional Homogeneity of the Anterior Cingulate Cortex in Depression. Neuropsychopharmacology, 40(7), 1640–1648. https://doi.org/10.1038/npp.2015.8
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Abstract
Major depressive disorder (MDD) is associated with structural and functional alterations in the prefrontal cortex (PFC) and anterior cingulate cortex (ACC). Enhanced ACC activity at rest (measured using various imaging methodologies) is found in treatment-responsive patients and is hypothesized to bolster treatment response by fostering adaptive rumination. However, whether structural changes influence functional coupling between fronto-cingulate regions and ACC regional homogeneity (ReHo) and whether these functional changes are rela
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- Späti, Jakub
- Hänggi, Jürgen
- Doerig, Nadja
- Ernst, Jutta
- Sambataro, Fabio
- Brakowski, Janis
- Jäncke, Lutz
- Grosse Holtforth, Martin
- Seifritz, Erich
- Spinelli, Simona
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Späti, J., Hänggi, J., Doerig, N., Ernst, J., Sambataro, F., Brakowski, J., Jäncke, L., Grosse Holtforth, M., Seifritz, E., & Spinelli, S. (2015). Prefrontal Thinning Affects Functional Connectivity and Regional Homogeneity of the Anterior Cingulate Cortex in Depression. Neuropsychopharmacology, 40(7), 1640–1648. https://doi.org/10.1038/npp.2015.8