Publication: Active eosinophils regulate host defense and immune responses in colitis
Active eosinophils regulate host defense and immune responses in colitis
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Gurtner, A., Borrelli, C., Gonzalez-Perez, I., Bach, K., Acar, I. E., Núñez, N. G., Crepaz, D., Handler, K., Vu, V. P., Lafzi, A., Stirm, K., Raju, D., Gschwend, J., Basler, K., Schneider, C., Slack, E., Valenta, T., Becher, B., Krebs, P., … Arnold, I. C. (2023). Active eosinophils regulate host defense and immune responses in colitis. Nature, 615, 151–157. https://doi.org/10.1038/s41586-022-05628-7
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In the past decade, single-cell transcriptomics has helped uncover new cell types and states and led to the construction of a cellular compendium of health and disease1. Still, some difficult-to-sequence cells remain absent from tissue atlases. Eosinophils, elusive granulocytes implicated in a plethora of human pathologies2,3, are among these uncharted cell types. To date, the heterogeneity of eosinophils and the gene programs underpinning their pleiotropic functions remain poorly understood4. In the present study, we provide the firs
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Gurtner, A., Borrelli, C., Gonzalez-Perez, I., Bach, K., Acar, I. E., Núñez, N. G., Crepaz, D., Handler, K., Vu, V. P., Lafzi, A., Stirm, K., Raju, D., Gschwend, J., Basler, K., Schneider, C., Slack, E., Valenta, T., Becher, B., Krebs, P., … Arnold, I. C. (2023). Active eosinophils regulate host defense and immune responses in colitis. Nature, 615, 151–157. https://doi.org/10.1038/s41586-022-05628-7