Publication: To incise or not and where: SET-domain methyltransferases know
To incise or not and where: SET-domain methyltransferases know
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Yancoskie, M. N., Maritz, C., van Eijk, P., Reed, S. H., & Naegeli, H. (2023). To incise or not and where: SET-domain methyltransferases know. Trends in Biochemical Sciences, 48(4), 321–330. https://doi.org/10.1016/j.tibs.2022.10.003
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The concept of the histone code posits that histone modifications regulate gene functions once interpreted by epigenetic readers. A well-studied case is trimethylation of lysine 4 of histone H3 (H3K4me3), which is enriched at gene promoters. However, H3K4me3 marks are not needed for the expression of most genes, suggesting extra roles, such as influencing the 3D genome architecture. Here, we highlight an intriguing analogy between the H3K4me3-dependent induction of double-strand breaks in several recombination events and the impact of
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- Yancoskie, Michelle N
- Maritz, Corina
- van Eijk, Patrick
- Reed, Simon H
- Naegeli, Hanspeter
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Yancoskie, M. N., Maritz, C., van Eijk, P., Reed, S. H., & Naegeli, H. (2023). To incise or not and where: SET-domain methyltransferases know. Trends in Biochemical Sciences, 48(4), 321–330. https://doi.org/10.1016/j.tibs.2022.10.003
