Publication: Validation of hypermethylated DNA regions found in colorectal cancers as potential aging-independent biomarkers of precancerous colorectal lesions
Validation of hypermethylated DNA regions found in colorectal cancers as potential aging-independent biomarkers of precancerous colorectal lesions
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Citations
Sajibu, S., Sonder, E., Tiwari, A., Orjuela, S., Parker, H. R., Frans, O. T., Gubler, C., Marra, G., & Robinson, M. D. (2023). Validation of hypermethylated DNA regions found in colorectal cancers as potential aging-independent biomarkers of precancerous colorectal lesions. BMC Cancer, 23(1), 998. https://doi.org/10.1186/s12885-023-11487-w
Abstract
Abstract
Abstract
BACKGROUND
We previously identified 16,772 colorectal cancer-associated hypermethylated DNA regions that were also detectable in precancerous colorectal lesions (preCRCs) and unrelated to normal mucosal aging. We have now conducted a study to validate 990 of these differentially methylated DNA regions (DMRs) in a new series of preCRCs.
METHODS
We used targeted bisulfite sequencing to validate these 990 potential biomarkers in 59 preCRC tissue samples (41 conventional adenomas, 18 sessile serrated lesions), each with a patient-match
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Creators (Authors)
- Sajibu, Sija
- Sonder, Emanuel
- Tiwari, Amit
- Orjuela, Stephany
- Parker, Hannah R
- Frans, Olivier The
- Gubler, Christoph
- Marra, Giancarlo
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Citations
Sajibu, S., Sonder, E., Tiwari, A., Orjuela, S., Parker, H. R., Frans, O. T., Gubler, C., Marra, G., & Robinson, M. D. (2023). Validation of hypermethylated DNA regions found in colorectal cancers as potential aging-independent biomarkers of precancerous colorectal lesions. BMC Cancer, 23(1), 998. https://doi.org/10.1186/s12885-023-11487-w
