Publication: Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes
Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes
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Kastrinou Lampou, V., Poller, B., Huth, F., Fischer, A., Kullak-Ublick, G. A., Arand, M., Schadt, H. S., & Camenisch, G. (2023). Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes. Toxicology in Vitro, 87, 105533. https://doi.org/10.1016/j.tiv.2022.105533
Abstract
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Abstract
Bile acid (BA) homeostasis is a complex and precisely regulated process to prevent impaired BA flow and the development of cholestasis. Several reactions, namely hydroxylation, glucuronidation and sulfation are involved in BA detoxification. In the present study, we employed a comprehensive approach to identify the key enzymes involved in BA metabolism using human recombinant enzymes, human liver microsomes (HLM) and human liver cytosol (HLC). We showed that CYP3A4 was a crucial step for the metabolism of several BAs and their taurine
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- Kastrinou Lampou, Vlasia
- Poller, Birk
- Huth, Felix
- Fischer, Audrey
- Kullak-Ublick, Gerd A
- Arand, Michael
- Schadt, Heiko S
- Camenisch, Gian
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Kastrinou Lampou, V., Poller, B., Huth, F., Fischer, A., Kullak-Ublick, G. A., Arand, M., Schadt, H. S., & Camenisch, G. (2023). Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes. Toxicology in Vitro, 87, 105533. https://doi.org/10.1016/j.tiv.2022.105533
