Tumor Oxygenation by Myo-Inositol Trispyrophosphate Enhances Radiation Response

Grgic, Ivo; Tschanz, Fabienne; Borgeaud, Nathalie; Gupta, Anurag; Clavien, Pierre-Alain; Guckenberger, Matthias; Graf, Rolf; Pruschy, Martin

doi:10.1016/j.ijrobp.2021.02.012

Citations

Citation copied

Grgic, I., Tschanz, F., Borgeaud, N., Gupta, A., Clavien, P.-A., Guckenberger, M., Graf, R., & Pruschy, M. (2021). Tumor Oxygenation by Myo-Inositol Trispyrophosphate Enhances Radiation Response. International Journal of Radiation Oncology, Biology, Physics, 110(4), 1222–1233. https://doi.org/10.1016/j.ijrobp.2021.02.012

Abstract

PURPOSE

Tumor hypoxia is a major limiting factor for successful radiation therapy outcomes, with hypoxic cells being up to 3-fold more radiation resistant than normoxic cells; tumor hypoxia creates a tumor microenvironment that is hostile to immune response. Thus, pharmaceutical-induced tumor oxygenation before radiation therapy represents an interesting method to enhance the efficacy of radiation therapy. Myo-inositol trispyrophosphate (ITPP) triggers a decrease in the affinity of oxygen to hemoglobin, which leads to an increased re