Ionic Liquids as Matrices in MicrofluidicSample Deposition for High-mass Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Abstract

Sample preparation for MALDI-MS via a microfluidic deposition device using ionic liquid matrices addresses several problems of standard protocols with crystalline matrices, such as the heterogeneity of sample spots due to the co-crystallization of sample and matrix, and the limited capability for high-throughput analysis. Since ionic liquid matrices do not solidify during the measurement, the resulting sample spots are homogeneous. The use of these matrices is also beneficial for automated sample preparation, since crystallization of Show more