Publication: lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs
lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs
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Savić, N., Bär, D., Leone, S., Frommel, S. C., Weber, F. A., Vollenweider, E., Ferrari, E., Ziegler, U., Kaech, A., Shakhova, O., Cinelli, P., & Santoro, R. (2014). lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs. Cell Stem Cell, 15(6), 720–734. https://doi.org/10.1016/j.stem.2014.10.005
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The open chromatin of embryonic stem cells (ESCs) condenses into repressive heterochromatin as cells exit the pluripotent state. How the 3D genome organization is orchestrated and implicated in pluripotency and lineage specification is not understood. Here, we find that maturation of the long noncoding RNA (lncRNA) pRNA is required for establishment of heterochromatin at ribosomal RNA genes, the genetic component of nucleoli, and this process is inactivated in pluripotent ESCs. By using mature pRNA to tether heterochromatin at nucleol
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- Savić, Nataša
- Bär, Dominik
- Leone, Sergio
- Frommel, Sandra C
- Weber, Fabienne A
- Vollenweider, Eva
- Ferrari, Elena
- Ziegler, Urs
- Kaech, Andres
- Shakhova, Olga
- Cinelli, Paolo
- Santoro, Raffaella
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Savić, N., Bär, D., Leone, S., Frommel, S. C., Weber, F. A., Vollenweider, E., Ferrari, E., Ziegler, U., Kaech, A., Shakhova, O., Cinelli, P., & Santoro, R. (2014). lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs. Cell Stem Cell, 15(6), 720–734. https://doi.org/10.1016/j.stem.2014.10.005