Publication: Oxygen supply maps for hypoxic microenvironment visualization in prostate cancer
Oxygen supply maps for hypoxic microenvironment visualization in prostate cancer
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Rupp, N. J., Schüffler, P. J., Zhong, Q., Falkner, F., Rechsteiner, M., Rüschoff, J. H., Fankhauser, C., Drach, M., Largo, R., Tremp, M., Poyet, C., Sulser, T., Kristiansen, G., Moch, H., Buhmann, J., Müntener, M., & Wild, P. J. (2016). Oxygen supply maps for hypoxic microenvironment visualization in prostate cancer. Journal of Pathology Informatics, 7, 3. https://doi.org/10.4103/2153-3539.175376
Abstract
Abstract
Abstract
BACKGROUND: Intratumoral hypoxia plays an important role with regard to tumor biology and susceptibility to radio- and chemotherapy. For further investigation of hypoxia-related changes, areas of certain hypoxia must be reliably detected within cancer tissues. Pimonidazole, a 2-nitroimindazole, accumulates in hypoxic tissue and can be easily visualized using immunohistochemistry. MATERIALS AND METHODS: To improve detection of highly hypoxic versus normoxic areas in prostate cancer, immunoreactivity of pimonidazole and a combination of
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Creators (Authors)
- Rupp, Niels J
- Schüffler, Peter J
- Zhong, Qing
- Falkner, Florian
- Rechsteiner, Markus
- Rüschoff, Jan H
- Fankhauser, Christian
- Drach, Matthias
- Largo, Remo
- Tremp, Mathias
- Poyet, Cedric
- Sulser, Tullio
- Kristiansen, Glen
- Moch, Holger
- Buhmann, Joachim
- Müntener, Michael
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Citations
Rupp, N. J., Schüffler, P. J., Zhong, Q., Falkner, F., Rechsteiner, M., Rüschoff, J. H., Fankhauser, C., Drach, M., Largo, R., Tremp, M., Poyet, C., Sulser, T., Kristiansen, G., Moch, H., Buhmann, J., Müntener, M., & Wild, P. J. (2016). Oxygen supply maps for hypoxic microenvironment visualization in prostate cancer. Journal of Pathology Informatics, 7, 3. https://doi.org/10.4103/2153-3539.175376
