Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial

Stahl, Klaus; Wand, Philipp; Seeliger, Benjamin; Wendel-Garcia, Pedro D; Schmidt, Julius; Schmidt, Bernhard M W; Sauer, Andrea; Lehmann, Felix; Budde, Ulrich; Busch, Markus; Wiesner, Olaf; Welte, Tobias; Haller, Hermann; Wedemeyer, Heiner; Putensen, Christian; Hoeper, Marius M; Bode, Christian; David, Sascha

doi:10.1186/s13054-022-04003-2

Citations

Citation copied

Stahl, K., Wand, P., Seeliger, B., Wendel-Garcia, P. D., Schmidt, J., Schmidt, B. M. W., Sauer, A., Lehmann, F., Budde, U., Busch, M., Wiesner, O., Welte, T., Haller, H., Wedemeyer, H., Putensen, C., Hoeper, M. M., Bode, C., & David, S. (2022). Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial. Critical Care, 26, 134. https://doi.org/10.1186/s13054-022-04003-2

Abstract

Background Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients with septic shock. Prediction of clinical efficacy in specific sepsis treatments is fundamental for individualized sepsis therapy.

Methods In the original RCT, patients with septic shock of < 24 h duration and norepinephrine (NE) requirement ≥ 0.4 μg/kg/min received standard of care (SOC) or SOC + one single TPE. Here, we report all clinical and biological end