Publication: Human RECQL5{beta} stimulates flap endonuclease 1
Human RECQL5{beta} stimulates flap endonuclease 1
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Speina, E., Dawut, L., Hedayati, M., Wang, Z., May, A., Schwendener, S., Janscak, P., Croteau, D. L., & Bohr, V. A. (2010). Human RECQL5{beta} stimulates flap endonuclease 1. Nucleic Acids Research, 38, 2904–2916. https://doi.org/10.1093/nar/gkp1217
Abstract
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Abstract
Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not been linked to any human disorder yet; cells devoid of RECQL1 and RECQL5 display increased chromosomal instability. Here, we report the physical and functional interaction of the large isomer of RECQL5, RECQL5beta, with the human flap endonuclease 1, FEN1, which plays a critical role
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Creators (Authors)
- Speina, E
- Dawut, L
- Hedayati, M
- Wang, Z
- May, A
- Schwendener, S
- Janscak, Pavel
- Croteau, D L
- Bohr, V A
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Citations
Speina, E., Dawut, L., Hedayati, M., Wang, Z., May, A., Schwendener, S., Janscak, P., Croteau, D. L., & Bohr, V. A. (2010). Human RECQL5{beta} stimulates flap endonuclease 1. Nucleic Acids Research, 38, 2904–2916. https://doi.org/10.1093/nar/gkp1217
