Publication: Concentration-dependent effects of dutasteride on prostate-specific membrane antigen (PSMA) expression and uptake of $^{177}$Lu-PSMA-617 in LNCaP cells
Concentration-dependent effects of dutasteride on prostate-specific membrane antigen (PSMA) expression and uptake of $^{177}$Lu-PSMA-617 in LNCaP cells
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Kranzbühler, B., Salemi, S., Umbricht, C. A., Deberle, L. M., Müller, C., Burger, I. A., Hermanns, T., Sulser, T., & Eberli, D. (2019). Concentration-dependent effects of dutasteride on prostate-specific membrane antigen (PSMA) expression and uptake of $^{177}$Lu-PSMA-617 in LNCaP cells. The Prostate, 79(12), 1450–1456. https://doi.org/10.1002/pros.23868
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BACKGROUND: Prostate-specific membrane antigen (PSMA)-based imaging and therapy are increasingly used in the management of prostate cancer. However, low PSMA surface expression in certain patients is a limitation for PSMA-based technologies. We have previously shown that high doses of dutasteride, a 5α-reductase inhibitor generally used for the treatment of benign prostatic enlargement, increase the PSMA expression in vitro. We now further analyzed the concentration- and time-dependent effects of dutasteride in LNCaP cells. METHODS: A
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- Kranzbühler, Benedikt
- Salemi, Souzan
- Umbricht, Christoph A
- Deberle, Luisa M
- Müller, Cristina
- Burger, Irene A
- Hermanns, Thomas
- Sulser, Tullio
- Eberli, Daniel
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Kranzbühler, B., Salemi, S., Umbricht, C. A., Deberle, L. M., Müller, C., Burger, I. A., Hermanns, T., Sulser, T., & Eberli, D. (2019). Concentration-dependent effects of dutasteride on prostate-specific membrane antigen (PSMA) expression and uptake of $^{177}$Lu-PSMA-617 in LNCaP cells. The Prostate, 79(12), 1450–1456. https://doi.org/10.1002/pros.23868
