Publication: The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
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Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, M., Tyagarajan, S. K., Robles, M. S., & Brown, S. A. (2019). The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science, 366(6462), eaav2642. https://doi.org/10.1126/science.aav2642
Abstract
Abstract
Abstract
Neurons have adapted mechanisms to traffic RNA and protein into distant dendritic and axonal arbors. Taking a biochemical approach, we reveal that forebrain synaptic transcript accumulation shows overwhelmingly daily rhythms, with two-thirds of synaptic transcripts showing time-of-day-dependent abundance independent of oscillations in the soma. These transcripts formed two sharp temporal and functional clusters, with transcripts preceding dawn related to metabolism and translation and those anticipating dusk related to synaptic transm
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Creators (Authors)
- Noya, Sara B
- Colameo, David
- Brüning, Franziska
- Spinnler, Andrea
- Mircsof, Dennis
- Opitz, Lennart
- Mann, Matthias
- Tyagarajan, Shiva K
- Robles, Maria S
- Brown, Steven A
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Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, M., Tyagarajan, S. K., Robles, M. S., & Brown, S. A. (2019). The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science, 366(6462), eaav2642. https://doi.org/10.1126/science.aav2642
