Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Disruptive Children and Adolescents

Werhahn, Julia E; Mohl, Susanna; Willinger, David; Smigielski, Lukasz; Roth, Alexander; et al; Walitza, Susanne; Brandeis, Daniel

doi:10.1101/599548

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Werhahn, J. E., Mohl, S., Willinger, D., Smigielski, L., Roth, A., et al, Walitza, S., & Brandeis, D. (2019). Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Disruptive Children and Adolescents (No. 599548; BioRxiv). https://doi.org/10.1101/599548

Abstract

BackgroundDisruptive behavior in children and adolescents can manifest itself in reactive (RA) and proactive (PA) aggression and is modulated by callous-unemotional (CU) traits and comorbidity. Research on aggression subtype-specific neural correlates is limited and the role of comorbid symptoms largely neglected.</jats:sec><jats:sec>MethodsThe current multi-center study extended previous efforts by investigating unrestricted resting state functional connectivity (rsFC) alterations. The large sample (n = 207) of children and adolescen