Publication: cAMP enhances BMP2-signaling through PKA and MKP1-dependent mechanisms
cAMP enhances BMP2-signaling through PKA and MKP1-dependent mechanisms
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Ghayor, C., Ehrbar, M., San Miguel, B., Grätz, K. W., & Weber, F. E. (2009). cAMP enhances BMP2-signaling through PKA and MKP1-dependent mechanisms. Biochemical and Biophysical Research Communications, 381, 247–252. https://doi.org/10.1016/j.bbrc.2009.02.032
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Recent studies suggest that the elevation of intracellular cyclic adenosine monophosphate (cAMP) and the activation of the protein kinase A regulate BMP-induced osteogenesis. However, the precise mechanisms underlying the enhancing effect of cAMP on BMP2 signaling were not completely revealed. In this study we investigated the effect of elevated cAMP level and PKA activation on the BMP2-induced osteoblastic differentiation in pluripotent C2C12 cells. Alkaline phosphatase activity and its mRNA were consistently induced by BMP2 treatmen
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- Ghayor, C
- San Miguel, B
- Grätz, K W
- Weber, Franz E
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Ghayor, C., Ehrbar, M., San Miguel, B., Grätz, K. W., & Weber, F. E. (2009). cAMP enhances BMP2-signaling through PKA and MKP1-dependent mechanisms. Biochemical and Biophysical Research Communications, 381, 247–252. https://doi.org/10.1016/j.bbrc.2009.02.032
