Publication: APOBECs orchestrate genomic and epigenomic editing across health and disease
APOBECs orchestrate genomic and epigenomic editing across health and disease
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Cervantes-Gracia, K., Gramalla-Schmitz, A., Weischedel, J., & Chahwan, R. (2021). APOBECs orchestrate genomic and epigenomic editing across health and disease. Trends in Genetics : Tig, 37(11), 1028–1043. https://doi.org/10.1016/j.tig.2021.07.003
Abstract
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Abstract
APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective manner. APOBECs function in various cellular compartments and recognize different nucleic acid motifs and structures. They orchestrate a wide array of genomic and epigenomic modifications, thereby affecting various cellular functions positively or negatively, including immune editing, viral and retroelement restriction, DNA damage responses, DNA demethylation, gene expre
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- Cervantes-Gracia, Karla
- Gramalla-Schmitz, Anna
- Weischedel, Julian
- Chahwan, Richard
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Cervantes-Gracia, K., Gramalla-Schmitz, A., Weischedel, J., & Chahwan, R. (2021). APOBECs orchestrate genomic and epigenomic editing across health and disease. Trends in Genetics : Tig, 37(11), 1028–1043. https://doi.org/10.1016/j.tig.2021.07.003
