Publication: Conserved stromal-immune cell circuits secure B cell homeostasis and function
Conserved stromal-immune cell circuits secure B cell homeostasis and function
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Lütge, M., De Martin, A., Gil-Cruz, C., Perez-Shibayama, C., Stanossek, Y., Onder, L., Cheng, H.-W., Kurz, L., Cadosch, N., Soneson, C., Robinson, M. D., Stoeckli, S. J., Ludewig, B., & Pikor, N. B. (2023). Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nature Immunology, 24, 1149–1160. https://doi.org/10.1038/s41590-023-01503-3
Abstract
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Abstract
B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being orchestrated across lymphoid organs. However, a comprehensive understanding of systemic humoral immunity is hampered by the lack of knowledge of global BRC sustenance, function and major pathways controlling BRC-immune cell interactions. Here we dissected the BRC landscape and immune cell interactome in human and murine lymphoid organs. In addition to the major BRC subsets underpinnin
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- Lütge, Mechthild
- De Martin, Angelina
- Gil-Cruz, Cristina
- Perez-Shibayama, Christian
- Stanossek, Yves
- Onder, Lucas
- Cheng, Hung-Wei
- Kurz, Lisa
- Cadosch, Nadine
- Soneson, Charlotte
- Stoeckli, Sandro J
- Ludewig, Burkhard
- Pikor, Natalia B
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Lütge, M., De Martin, A., Gil-Cruz, C., Perez-Shibayama, C., Stanossek, Y., Onder, L., Cheng, H.-W., Kurz, L., Cadosch, N., Soneson, C., Robinson, M. D., Stoeckli, S. J., Ludewig, B., & Pikor, N. B. (2023). Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nature Immunology, 24, 1149–1160. https://doi.org/10.1038/s41590-023-01503-3
