Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

Degirmenci, Bahar; Dincer, Cansu; Demirel, Habibe Cansu; Berkova, Linda; Moor, Andreas E; Kahraman, Abdullah; Hausmann, George; Aguet, Michel; Tuncbag, Nurcan; Valenta, Tomas; Basler, Konrad

doi:10.5167/uzh-211149

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Degirmenci, B., Dincer, C., Demirel, H. C., Berkova, L., Moor, A. E., Kahraman, A., Hausmann, G., Aguet, M., Tuncbag, N., Valenta, T., & Basler, K. (2021). Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. IScience, 24, 103369. https://doi.org/10.1016/j.isci.2021.103369

Abstract

Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need for Wnts. Here we describe a class of colon cancer that does not depend on mutated core components of the Wnt pathway. Genetically blocking Wnt secretion from epithelial cells of such tumors results in apoptosis, reduced expression of colon cancer markers, followed by enhanced tumor d