Publication: Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair.
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair.
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Missura, M., Buterin, T., Hindges, R., Hübscher, U., Kaspárková, J., Brabec, V., & Naegeli, H. (2001). Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair. The EMBO Journal, 20, 3554–3564. https://doi.org/10.1093/emboj/20.13.3554
Abstract
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Abstract
The multiprotein factor composed of XPA and replication protein A (RPA) is an essential subunit of the mammalian nucleotide excision repair system. Although XPA-RPA has been implicated in damage recognition, its activity in the DNA repair pathway remains controversial. By replacing DNA adducts with mispaired bases or non-hybridizing analogues, we found that the weak preference of XPA and RPA for damaged substrates is entirely mediated by indirect readout of DNA helix conformations. Further screening with artificially distorted substra
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Creators (Authors)
- Missura, M
- Buterin, T
- Hindges, R
- Hübscher, U
- Kaspárková, J
- Brabec, V
- Naegeli, H
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Missura, M., Buterin, T., Hindges, R., Hübscher, U., Kaspárková, J., Brabec, V., & Naegeli, H. (2001). Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair. The EMBO Journal, 20, 3554–3564. https://doi.org/10.1093/emboj/20.13.3554
