Publication: Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin‐producing cells
Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin‐producing cells
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Bapst, A. M., Knöpfel, T., Nolan, K. A., Imeri, F., Schuh, C. D., Hall, A. M., Guo, J., Katschinski, D. M., & Wenger, R. H. (2022). Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin‐producing cells. Journal of Cellular Physiology, 237(5), 2420–2433. https://doi.org/10.1002/jcp.30677
Abstract
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Abstract
In adult mammals, the kidney is the main source of circulating erythropoietin (Epo), the master regulator of erythropoiesis. In vivo data in mice demonstrated multiple subtypes of interstitial renal Epo-producing (REP) cells. To analyze the differentiation plasticity of fibroblastoid REP cells, we used a transgenic REP cell reporter mouse model to generate conditionally immortalized REP-derived (REPD) cell lines. Under nonpermissive conditions, REPD cells ceased from proliferation and acquired a stem cell-like state, with strongly enh
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- Knöpfel, Thomas
- Nolan, Karen A
- Imeri, Faik
- Schuh, Claus D
- Hall, Andrew M
- Guo, Jia
- Katschinski, Dörthe M
- Wenger, Roland H
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Bapst, A. M., Knöpfel, T., Nolan, K. A., Imeri, F., Schuh, C. D., Hall, A. M., Guo, J., Katschinski, D. M., & Wenger, R. H. (2022). Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin‐producing cells. Journal of Cellular Physiology, 237(5), 2420–2433. https://doi.org/10.1002/jcp.30677
