Publication: Characterization of ROMK cellular heterogeneity along the mouse kidney thick ascending limb
Characterization of ROMK cellular heterogeneity along the mouse kidney thick ascending limb
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Keller, C., Santos, R. R., van Megen, W. H., & Loffing, J. (2025). Characterization of ROMK cellular heterogeneity along the mouse kidney thick ascending limb. Pflügers Archiv : European Journal of Physiology, 477(6), 841–856. https://doi.org/10.1007/s00424-025-03086-4
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The renal thick ascending limb (TAL) plays a key role in water and ion homeostasis. Apical potassium secretion via the renal outer medullary potassium channel (ROMK) is essential for transepithelial sodium reabsorption via the furosemide-sensitive Na-K-2Cl-cotransporter and creates the electrochemical gradient for paracellular ion transport through Claudin tight junction proteins. Interestingly, the TAL exhibits transcriptomic heterogeneity and variable apical ROMK abundance. Single-cell RNA sequencing suggests that the cortical TAL c
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- Keller, Christian
- Santos, Rui Ramos
- van Megen, Wouter H
- Loffing, Johannes
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Keller, C., Santos, R. R., van Megen, W. H., & Loffing, J. (2025). Characterization of ROMK cellular heterogeneity along the mouse kidney thick ascending limb. Pflügers Archiv : European Journal of Physiology, 477(6), 841–856. https://doi.org/10.1007/s00424-025-03086-4
