Publication: Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer
Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer
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Goetze, S., Schüffler, P., Athanasiou, A., Koetemann, A., Poyet, C., Fankhauser, C. D., Wild, P. J., Schiess, R., & Wollscheid, B. (2022). Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer. Clinical Proteomics, 19, 9. https://doi.org/10.1186/s12014-022-09349-x
Abstract
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BACKGROUND
Non-invasive liquid biopsies could complement current pathological nomograms for risk stratification of prostate cancer patients. Development and testing of potential liquid biopsy markers is time, resource, and cost-intensive. For most protein targets, no antibodies or ELISAs for efficient clinical cohort pre-evaluation are currently available. We reasoned that mass spectrometry-based prescreening would enable the cost-effective and rational preselection of candidates for subsequent clinical-grade ELISA development.
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- Goetze, Sandra
- Schüffler, Peter
- Athanasiou, Alcibiade
- Koetemann, Anika
- Poyet, Cedric
- Fankhauser, Christian Daniel
- Wild, Peter J
- Schiess, Ralph
- Wollscheid, Bernd
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Goetze, S., Schüffler, P., Athanasiou, A., Koetemann, A., Poyet, C., Fankhauser, C. D., Wild, P. J., Schiess, R., & Wollscheid, B. (2022). Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer. Clinical Proteomics, 19, 9. https://doi.org/10.1186/s12014-022-09349-x
