Publication: Detrusor bioengineering using a cell-enriched compressed collagen hydrogel
Detrusor bioengineering using a cell-enriched compressed collagen hydrogel
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Smolar, J., De Nardo, D., Reichmann, E., Gobet, R., Eberli, D., & Horst, M. (2020). Detrusor bioengineering using a cell-enriched compressed collagen hydrogel. Journal of Biomedical Materials Research. Part B, 108(7), 3045–3055. https://doi.org/10.1002/jbm.b.34633
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OBJECTIVE: The gold standard for bladder regeneration in end-stage bladder disease is the use of intestinal tissue, which is however associated with significant long-term complications. Our study aims to bioengineer functional detrusor muscle combining bladder smooth muscle cells (SMC) and SMC-like adipose-derived stem cells (pADSC) in compressed collagen (CC) hydrogels and to investigate biocompatibility and tissue regeneration of such detrusor-equivalents in a rat detrusorectomy model. METHODS: Compressed collagen hydrogels seeded w
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- Smolar, Jakub
- De Nardo, Daniele
- Reichmann, Ernst
- Gobet, Rita
- Eberli, Daniel
- Horst, Maya
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Smolar, J., De Nardo, D., Reichmann, E., Gobet, R., Eberli, D., & Horst, M. (2020). Detrusor bioengineering using a cell-enriched compressed collagen hydrogel. Journal of Biomedical Materials Research. Part B, 108(7), 3045–3055. https://doi.org/10.1002/jbm.b.34633
