Publication: Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models
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Freitag, T. L., Fagerlund, R., Karam, N. L., Leppänen, V.-M., Uğurlu, H., Kant, R., Mäkinen, P., Tawfek, A., Jha, S. K., Strandin, T., Leskinen, K., Hepojoki, J., Kesti, T., Kareinen, L., Kuivanen, S., Koivulehto, E., Sormunen, A., Laidinen, S., Khattab, A., … Saksela, K. (2023). Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models. Vaccine, 41, 3233–3246. https://doi.org/10.1016/j.vaccine.2023.04.020
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The ongoing SARS-CoV-2 pandemic is controlled but not halted by public health measures and mass vaccination strategies which have exclusively relied on intramuscular vaccines. Intranasal vaccines can prime or recruit to the respiratory epithelium mucosal immune cells capable of preventing infection. Here we report a comprehensive series of studies on this concept using various mouse models, including HLA class II-humanized transgenic strains. We found that a single intranasal (i.n.) dose of serotype-5 adenoviral vectors expressing eit
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- Freitag, Tobias L
- Fagerlund, Riku
- Karam, Nihay Laham
- Leppänen, Veli-Matti
- Uğurlu, Hasan
- Kant, Ravi
- Mäkinen, Petri
- Tawfek, Ahmed
- Jha, Sawan Kumar
- Strandin, Tomas
- Leskinen, Katarzyna
- Hepojoki, Jussi
- Kesti, Tapio
- Kareinen, Lauri
- Kuivanen, Suvi
- Koivulehto, Emma
- Sormunen, Aino
- Laidinen, Svetlana
- Khattab, Ayman
- Saavalainen, Päivi
- Meri, Seppo
- Kipar, Anja
- Sironen, Tarja
- Vapalahti, Olli
- Alitalo, Kari
- Ylä-Herttuala, Seppo
- Saksela, Kalle
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Freitag, T. L., Fagerlund, R., Karam, N. L., Leppänen, V.-M., Uğurlu, H., Kant, R., Mäkinen, P., Tawfek, A., Jha, S. K., Strandin, T., Leskinen, K., Hepojoki, J., Kesti, T., Kareinen, L., Kuivanen, S., Koivulehto, E., Sormunen, A., Laidinen, S., Khattab, A., … Saksela, K. (2023). Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models. Vaccine, 41, 3233–3246. https://doi.org/10.1016/j.vaccine.2023.04.020
