Publication: Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis
Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis
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Blyszczuk, P., Müller-Edenborn, B., Valenta, T., Osto, E., Stellato, M., Behnke, S., Glatz, K., Basler, K., Lüscher, T. F., Distler, O., Eriksson, U., & Kania, G. (2017). Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. European Heart Journal, 38(18), 1413–1425. https://doi.org/10.1093/eurheartj/ehw116
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AIMS: Myocardial fibrosis critically contributes to cardiac dysfunction in inflammatory dilated cardiomyopathy (iDCM). Activation of transforming growth factor-β (TGF-β) signalling is a key-step in promoting tissue remodelling and fibrosis in iDCM. Downstream mechanisms controlling these processes, remain elusive. METHODS AND RESULTS: Experimental autoimmune myocarditis (EAM) was induced in BALB/c mice with heart-specific antigen and adjuvant. Using heart-inflammatory precursors, as well as mouse and human cardiac fibroblasts, we demo
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- Blyszczuk, Przemyslaw
- Müller-Edenborn, Björn
- Valenta, Tomas
- Osto, Elena
- Stellato, Mara
- Behnke, Silvia
- Glatz, Katharina
- Lüscher, Thomas F
- Distler, Oliver
- Eriksson, Urs
- Kania, Gabriela
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Blyszczuk, P., Müller-Edenborn, B., Valenta, T., Osto, E., Stellato, M., Behnke, S., Glatz, K., Basler, K., Lüscher, T. F., Distler, O., Eriksson, U., & Kania, G. (2017). Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. European Heart Journal, 38(18), 1413–1425. https://doi.org/10.1093/eurheartj/ehw116
