Publication: TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription
TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription
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Cavadini, G., Petrzilka, S., Kohler, P., Jud, C., Tobler, I., Birchler, T., & Fontana, A. (2007). TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proceedings of the National Academy of Sciences of the United States of America, 104(31), 12843–12848. https://doi.org/10.1073/pnas.0701466104
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Production of TNF-alpha and IL-1 in infectious and autoimmune diseases is associated with fever, fatigue, and sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice TNF-alpha and IL-1 increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm and thereby locomotor activity and may alter sleep architecture we assessed the influence of TNF-alpha on the circadian timing system. TNF-alpha is shown here to suppress the expression of the PAR bZip clock-controlled genes Dbp,
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- Cavadini, G
- Petrzilka, S
- Kohler, P
- Jud, C
- Tobler, I
- Birchler, T
- Fontana, A
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Cavadini, G., Petrzilka, S., Kohler, P., Jud, C., Tobler, I., Birchler, T., & Fontana, A. (2007). TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proceedings of the National Academy of Sciences of the United States of America, 104(31), 12843–12848. https://doi.org/10.1073/pnas.0701466104
