Publication: Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging
Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging
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Esipova, T. V., Barrett, M. J. P., Erlebach, E., Masunov, A. E., Weber, B., & Vinogradov, S. A. (2019). Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging. Cell Metabolism, 29(3), 736-744.e7. https://doi.org/10.1016/j.cmet.2018.12.022
Abstract
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Quantitative imaging of oxygen distributions in tissue can provide invaluable information about metabolism in normal and diseased states. Two-photon phosphorescence lifetime microscopy (2PLM) has been developed to perform measurements of oxygen in vivo with micron-scale resolution in 3D; however, the method’s potential has not yet been fully realized due to the limitations of current phosphorescent probe technology. Here, we report a new sensor, Oxyphor 2P, that enables oxygen microscopy twice as deep (up to 600 μm below the tissue su
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- Esipova, Tatiana V
- Barrett, Matthew J P
- Erlebach, Eva
- Masunov, Artëm E
- Weber, Bruno
- Vinogradov, Sergei A
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Citations
Esipova, T. V., Barrett, M. J. P., Erlebach, E., Masunov, A. E., Weber, B., & Vinogradov, S. A. (2019). Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging. Cell Metabolism, 29(3), 736-744.e7. https://doi.org/10.1016/j.cmet.2018.12.022
