Publication: Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout
Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout
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Muhia, M., Willadt, S., Yee, B. K., Feldon, J., Paterna, J.-C., Schwendener, S., Vogt, K., Kennedy, M. B., & Knuesel, I. (2012). Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout. Learning & Memory, 19, 268–281. https://doi.org/10.1101/lm.026351.112
Abstract
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Abstract
The synaptic Ras/Rap-GTPase-activating protein (SynGAP1) plays a unique role in regulating specific downstream intracellular events in response to N-methyl-D-aspartate receptor (NMDAR) activation. Constitutive heterozygous loss of SynGAP1 disrupts NMDAR-mediated physiological and behavioral processes, but the disruptions might be of developmental origin. Therefore, the precise role of SynGAP1 in the adult brain, including its relative functional significance within specific brain regions, remains unexplored. The present study constitu
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- Muhia, Mary
- Willadt, Silvia
- Yee, Benjamin K
- Feldon, Joram
- Paterna, Jean-Charles
- Schwendener, Severin
- Vogt, Kaspar
- Kennedy, Mary B
- Knuesel, Irene
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Muhia, M., Willadt, S., Yee, B. K., Feldon, J., Paterna, J.-C., Schwendener, S., Vogt, K., Kennedy, M. B., & Knuesel, I. (2012). Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout. Learning & Memory, 19, 268–281. https://doi.org/10.1101/lm.026351.112
